Document Type : Original Research Article
Authors
1
Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2
Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3
Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4
Medical Doctor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5
Assistant Professor, Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background & aim: Misoprostol is widely used for first-trimester abortion. This study aims to assess the success rate and side effects of outpatient versus inpatient vaginal misoprostol administration for first-trimester abortion.
Methods: A prospective randomized trial included women with first-trimester abortion (≤14 week’s gestation) referred to three educational hospitals of Mashhad University of Medical Sciences in 2019-2020. Patients were randomly assigned to receive vaginal misoprostol either as inpatients or as outpatients. Intra-vaginal misoprostol 800 mcg was administered every twenty-four hours up to two doses. Treatment success, the primary outcome, was defined as complete evacuation after one or two doses. Elective curettage was performed if complete evacuation failed after one week, and emergent curettage was considered in cases of heavy vaginal bleeding. Data analysis utilized SPSS software (version 19.0) and included the Independent t-test, Chi-square test, and Logistic regression model. A significance level of P<0.05 was set.
Results: Success rates for outpatient and inpatient treatments were 96.6% and 91.5%, respectively, showing no significant difference (p = 0.167). Additionally, side effects did not significantly differ between inpatient and outpatient groups (p = 0.698).
Conclusion: Vaginal misoprostol (800 mcg every twenty-four hours for a maximum of two doses) in an outpatient setting is as effective as in an inpatient condition with similar side effects. Outpatient medical abortion can be a viable alternative to hospitalization
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