Female Urethral Condyloma Acuminata Causing Lower Urinary Tract Symptoms: Report of Two Cases

Document Type : Case Report

Authors

1 a) Associate Professor, Supporting the Family and the Youth of Population Research Core, Mashhad University of Medical Sciences, Mashhad, Iran b) Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant professor, Department of Urology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Associate professor, Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 Gynecologist, Department of Obstetrics and Gynecology School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5 Associate Professor, Supporting the Family and the Youth of Population Research Core, Mashhad University of Medical Sciences, Mashhad, Iran

10.22038/jmrh.2024.72431.2121

Abstract

Background & aim: Female urethral involvement is rare in Human papillomavirus (HPV) infections, even though HPV is the most common sexually transmitted disease globally.This case report aimed to present two unusual cases of HPV infection of the female urethra, which caused lower urinary tract symptoms.
Case report: A 45-year-old single woman was referred complaining of mass protrusion from the urethral meatus, incomplete voiding, and dysuria in the last three months. Physical examination revealed a papillary pink mass about 0.5×1 cm in diameter around the external urethral meatus. A surgical excision was performed. Pathological evaluation revealed condyloma acuminatum. The next case was a 41-year-old married woman referred to the clinic with a complaint of dysuria. Physical examination revealed a purple urethral mass about 0.5×0.5 cm in size. A surgical excision was performed, and histopathological evaluation showed condyloma acuminatum. After two months of follow-up, they had no recurrent lesions or symptoms.
Conclusion: Female urethral condyloma acuminata may cause lower urinary tract symptoms. Surgical excision of urethral condyloma is an effective treatment.

Keywords

Main Subjects


  1. De Camargo CC, Tasca KI, Mendes MB, Miot HA, de Souza Ldo R. Prevalence of Anogenital Warts in Men with HIV/AIDS and Associated Factors. Open AIDS Journal. 2014; 8: 25-30. 
  2. Prevention of genital HPV infection and sequelae: report of an external consultants' meeting. Atlanta, GA: Centers for Disease Control and Prevention. Available at: www. cdc.gov/ std/hpv/hpvsupplement99.pdf (Accessed on February 08, 2016)
  3. Aubin F, Prétet JL, Jacquard AC, Saunier M, Carcopino X, Jaroud F, et al. Human papillomavirus genotype distribution in external acuminata condylomata: a Large French National Study (EDiTH IV). Clinical Infectious Diseases. 2008; 47(5): 610-615.
  4. Steben M, LaBelle D. Genital warts: Canadians’ perception, health-related behaviors, and treatment preferences. Journal of lower Genital Tract Disease. 2012; 16(4): 409-415.
  5. Hamano I, Hatakeyama S, Yamamoto H, Fujita T, Murakami R, Shimada M, et al. Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report. Transplantation Proceedings. 2018; 50(8): 2553-2557.
  6. Cinar O, Bolat MS, Akdeniz E, Sahinkaya N. A rare cause of acute urinary retention in women: meatal condyloma accuminata, a case report. Pan African Medical Journal. 2016; 24(1).
  7. Cone MM, Cone MM, Whitlow CB. Sexually transmitted and anorectal infectious diseases. Gastroenterology Clinics. 2013; 42(4): 877-892.
  8. Chae JY, Chae JY, Bae JH, Yoon CY, Park HS, Moon DG, Lee JG, Oh MM. Female urethral condyloma causing bladder outlet obstruction. International Neurourology Journal. 2014; 18(1): 42.
  9. Jones HW, Rock JA. TeLinde's Operative Gynecology.12th edition. Philadelphia: Wolters Kluwer, 2020. P.1080.
  10. Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recommendations and Reports 2015 Jun 5;64(RR-03):1-137.
  11. Berek JS. Berek and Novak's Gynecology. 16th ed. chapter 16. Francisco Garcia, Kenneth D. Hatch, Jonathan S. Berek Lippincott Williams & Wilkins: 2020. P. 386.
  12. Fathi R, Tsoukas MM. Genital warts and other HPV infections: established and novel therapies. Clin Dermatol. 2014; 32(2): 299-306. 
  13. Stern PL, van der Burg SH, Hampson IN, Broker TR, Fiander A, Lacey CJ, Kitchener HC, Einstein MH. Therapy of human papillomavirus-related disease. Vaccine. 2012; 30: F71-F82.
  14. Widschwendter A, Böttcher B, Riedl D, Coban S, Mutz-Dehbalaie I, Matteucci Gothe R, Ciresa-König A, Marth C, Fessler S. Recurrence of genitals warts in pre-HPV vaccine era after laser treatment. Archives of Gynecology and Obstetrics. 2019; 300(3): 661-668.
  15. Puviani M, Galluzzo M, Talamonti M, Mazzilli S, Campione E, Bianchi L, Milani M, Luppino I, Micali G. Efficacy of sinecatechins 10% as proactive sequential therapy of external genital warts after laser CO2 ablative therapy: The PACT study (post-ablation immunomodulator treatment of condylomata with sinecatechins): a randomized, masked outcome assessment, multicenter trial. International Journal of STD & AIDS. 2019; 30(2): 131-136.