Spontaneous Pregnancy Following 6-Month Herbal Medicine Treatment for the Subclinical Stage of Premature Ovarian Insufficiency: A Case Report

Document Type : Case Report


1 a) PhD Student, Shandong University of Traditional Chinese Medicine, China b) Department of Chinese Medicine, Centre for Complementary and Alternative Medicine, International Medical University, Malaysia

2 MSc Student, Shandong University of Traditional Chinese Medicine, China

3 Professor, Shandong University of Traditional Chinese Medicine Affiliated Hospital, China


Background and aim: Premature ovarian insufficiency (POI) in women under 40 leads to infertility and psychological distress. Timely diagnosis of POI is vital to prevent progression to ovarian failure. Chinese herbal medicine has shown efficacy in treating the subclinical stage of POI, aligning with the preventive approach of Chinese medicine.
Case presentation: A 29-year-old with subclinical POI received exclusive herbal medicine treatment. After six months, she achieved spontaneous conception, with an AMH level of 0.41 ng/mL and FSH at 14.96 mIU/mL. Ultrasound revealed increased antral follicle count post-treatment. Without assisted reproductive technology, she delivered a healthy full-term baby.
Conclusion: Successful subclinical POI treatment with Chinese herbal medicine resulted in a safe, spontaneous pregnancy. This case underscores diagnostic challenges in POI, emphasizing the necessity of adhering to criteria. Despite the lack of guidelines, Chinese herbal medicine shows promise for follicular growth in POI. Valuable insights contribute to learning points, emphasizing the potential for natural conception without assisted reproductive technology—an indication of the efficacy of integrative approaches in subclinical POI management.


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